Although gelatin capsules are simple to produce, the gelatin can facilitate growth of bacteria. It is therefore important that gelatin capsules are inspected and analyzed to check for any signs of bacterial growth. Another aspect that must be considered is that gelatin is produced from animal bones and are therefore unsuitable for strict vegetarians. To overcome this, there are vegetarian forms available made from a form of cellulose called hypromellose.
Gelatin capsules vary in size depending on the requirement. They range from between 0.13 mL to 28 mL capacity. Gelatin capsules are commonly used in the pharmaceutical industry as containers for drugs. Not only are they easy to manufacture, but they do not require complex formulations to produce unlike some other drug containers
Hard gelatin capsules, unlike the soft form, are made of two parts, the body and the cap, each of a different color. This form of capsule holds dry ingredients in powder form. The body is first filled with the mix of active ingredients and any excipients used, and then closed with the cap using either a manual or automatic press machine.
Once ingested, the hard capsules disintegrate within three minutes and quickly release the drug inside. Hard gelatin capsules are also hygroscopic and contain a higher water content than the soft capsules at around 12-15%. Some drugs need to be released at certain points in the body, and therefore the capsule must release the drug at an earlier time. To enable this, the capsule can be filled with target release pellets. As well as powdered ingredients, the gelatin capsules can also be used to cover premade tablets.
The process of encapsulation of hard gelatin capsules can be done on manual, semi-automatic and automatic capsule filling machines. They are filled at the same time as they are produced and sealed on the rotary die of a fully automatic machine. Capsule fill weight is a critical attribute in encapsulation and various real time fill weight monitoring techniques such as near-infrared) and vibrational spectroscopy are used. It is prepared by hydrolysis of collagen obtained from animal connective tissue, bone and pork skin.
There are various steps that are involved in manufacturing of hard gelatin capsules, they are describesbelow:
INGREDIENTS ADDED TO MAKE HARD CAPSULE:
The most important good thing about choosing herbal supplements in Gelatin Capsules is that they are available at a reasonable price than vegetable capsules. It is one of the most common reasons that a buyer considers in mind when purchasing between the two forms of capsules. There are other health benefits of preferring these capsules, which contains –
Halal gelatin is one of the largest manufacturer of gelatin in Pakistan. They supply gelatin not only in Pakistan but around the globe like Iran, Malaysia, Indonesia, Turkey and Germany.